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Home > 師資類別>專任教師>簡志青
111_111_CCC2
簡志青  副教授
: (03)4638800 分機2184
: ccchien@saturn.yzu.edu.tw
研究室 : 二館五樓2518室
實驗室 : 微生物生理與生化實驗室(2321室)

學歷

台北醫學院醫事技術學系理學士
(BS, Medical Technology, Taipei Medical College)
美國康乃迪克大學微生物學碩士
(MS, Microbiology, University of Connecticut)
美國康乃迪克大學微生物學博士
(Ph.D., Microbiology, University of Connecticut)

經歷

美國麻州海洋生物實驗室,1995年 微生物多樣性學員
(Microbial Diversity, Marine Biological Laboratory, Woods Hole, MA)
麻省理工學院博士後研究
(Postdoctoral associate, Division of Comparative Medicine, Massachusetts Institute of Technology)
加州理工學院助理科學家
(Assistant Scientist, Division of Geological and Planetary Science, California Institute of Technology)
工研院生醫工程中心分子生醫技術組研究員
(Researcher, Biomedical Engineering Center, Industrial Technology Research Institute)
工研院生醫工程中心分子生醫技術組蛋白體技術部副經理
(Deputy Manager, Proteomics department, Biomedical Engineering Center, Industrial Technology Research Institute)

研究專長

(1) 微生物生理與生化 (Microbial physiology and biochemistry)
(2) 微生物多樣性與環境微生物 (Microbial diversity, ecology and environmental microbiology)
(3) 微生物生物降解/分子生物技術 (基因體與蛋白質體學) (Microbial bioremediation /Molecular biology (genomics, proteomics))
(4) 工業與應用微生物 (Industrial and Applied Microbiology)

得獎或研究成果
代表作

A. 期刊論文 (Since 2005)
 
(1)       Chien C-C* , Kao C-M, Chen D-Y, Chen SC, Chen C-C. (2014) Biotransformation of trinitrotoluene (TNT) by Pseudomonas spp. isolated from a TNT-contaminated environment. Environ Toxicol Chem  (Accepted) [SCI]
(2)       Chien C-C *, Wang L-J, Lin W-R (2014) Polyhydroxybutyrate accumulation by a cadmium-resistant strain of Cupriavidus taiwanensis. J Taiwan Ins Chem Eng (Accepted)[SCI]
(3)       Chen, L.-C., Chueh, T.-C., Tuan, Y.-F., Chen, C.-C., Chien, C.-C., Lee, H.-Y., Chen, S.-C.* (2014) Activation of MAPK pathways and downstream transcription factors in 2-aminobiphenyl-induced apoptosis.  Environ Toxicol (In press) [SCI]
(4)       Chien, C.-C.*, Lin, B.-C., Wu, C.-H. (2013) Biofilm formation and heavy metal resistance by an environmental Pseudomonas sp. Biochem Eng J 78:132-137. [SCI]
(5)       Chen, W.-C., Yu, W.-J., Chang, C.-C., Chang, J.-S., Huang, S.-H., Chang, C.-H., Chen, S.-Y., Chien, C.-C., Yao, C.-L., Chen, W-M., Wei, Y.-H.* (2013) Enhancing production of prodigiosin from Serratia marcescens C3 by statistical experimental design and porous carrier addition strategy. Biochem Eng J 78:93-100. [SCI]
(6)       Horng, Y.-T., Chien, C.-C., Huang, C.-T., Wei, Y.-H., Chen, S.-Y., Lan, J.C.-W., Soo, P.-C.* (2013) Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with co-expressed propionate permease (prpP), beta-ketothiolase B (bktB), and propionate-CoA synthase (prpE) in Escherichia coli.  Biochem Eng J 78:73-79. [SCI]
(7)       Chien, C.-C.*, Huang, C.-H., Lin, Y.-W. (2013) Characterization of a heavy metal translocating P-type ATPase gene from an environmental heavy metal resistance Enterobacter sp. isolate.  Appl Biochem Biotechnol 169(6): 1837-1846. [SCI]
(8)       Chien, C-C.*, Li, H-H., Soo, P-C., Chen, S-Y., Wei, Y-H., Chen, W-M. (2012) Effects of different substrate composition on biosynthesis of polyhydroxybutyrate-co-hydroxyvalerate by recombinant Escherichia coli.  Appl Biochem Biotechnol 166(3):  796-804. [SCI]
(9)       Chien, C-C.*, Jiang, M-H., Tsai, M-R., Chien, C-C. (2011) Isolation and characterization of an environmental cadmium and tellurite resistant Pseudomonas strain.  Environ Toxicol Chem 30(10): 2202-2207. [SCI].
(10)   Chu, F.-Y.*, Su, F.-H., Cheng, S.-H., Lin, Y.-S., Li, C.-Y., Chien, C.-C., Lin, Y.-C., Chiang, S.-Y. (2011)  Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis b virus infection in . J Med Virol 83:1514–1521. [SCI]
(11)   Horng, Y-T., Chien, C-C., Wei, Y-H., Chen, S-Y., Lan, J.C-W., Sun, Y-M., Soo, P-C.*  (2011) Functional cis-expression of phaCAB genes for poly(3-hydroxybutyrate) production by Escherichia coli.   Lett Appl Microbiol 52(5):475-483.  [SCI]
(12)   Chen S.C., Chen C. S., Zhan K-V., Yang K-H., Chien C-C., Shieh B-S., Chen W-M. (2011) Biodegradation of methyl tert-butyl ether (MTBE) by Enterobacter sp. NKNU02.  J Hazard Mater 186 (2-3): 1744-1750 [SCI]
(13)   Chien, C-C.*, Hong, C-C., Soo, P-C., Wei, Y-H., Chen, S-Y., Cheng, M-L., Sun, Y-M. (2010) Functional expression of phaCAB genes from Cupriavidus taiwanensis strain 184 in Escherichia coli for polyhydroxybutyrate production. Appl Biochem Biotechnol 162(8):2355–2364 [SCI]
(14)   Horng, Y-T., Chang, K-C., Chou, T-C., Yu, C-J., Chien, C-C., Wei, Y-H., Soo, P-C.* (2010) Inactivation of dhaD and dhaK abolishes by-product accumulation during 1,3-propanediol production in Klebsiella pneumoniae.  J Ind Microbiol Biotechnol 37(7):707–716.  [SCI]
(15)   Kao, C-M., Chen, CS., Tsa, F-Y., Yang, K-H., Chien, C-C., Liang, S-H., Yang, C-A., Chen, SC.* (2010) Application of real-time PCR, DGGE fingerprinting, and culture-based method to evaluate the effectiveness of intrinsic bioremediation on the control of petroleum-hydrocarbon plume.   J Hazard Mater 178(1-3):409-416.  [SCI]
(16)   Horng, Y-T., Chang, K-C., Chien, C-C., Wei, Y-H., Sun, Y-M., Soo, P-C.* (2010)   Enhanced polyhydroxybutyrate (PHB) production via the coexpressed phaCAB and vgb genes controlled by arabinose PBAD promoter in Escherichia coli. Lett Appl Microbiol 50(2): 158-167.  [SCI]
(17)   Hung, HF., Kuo, YM.*, Chien, CC., Chen, CC. (2010) Use of floating balls for reducing bacterial aerosol emissions from aeration in wastewater treatment processes.  J Hazard Mater 175(1-3):866-871.  [SCI]
(18)   Chien, C-C.*, Han, C-T. (2009) Tellurite resistance and reduction by a Paenibacillus sp. isolated from heavy metal–contaminated sediment.  Environ Toxicol Chem 28(8):1627-1632. [SCI]
(19)   Chien, C-C.*, Ho, L-Y. (2008) Polyhydroxyalkanoates production from carbohydrates by a genetic recombinant Aeromonas sp.  Lett Appl Microbiol  47:587-593.  [SCI]
(20)   Chien, C-C.*, Tsai, M-L., Chen, C-C., Chang, S-J., Tseng, C-H. (2008) Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms. Mycopathologia 166(2):117-120. [SCI]
(21)   Wei, Y-H.*, Cheng, C-L., Chien C-C., Wan, H-M. (2008) Enhanced di-rhamnolipid production with an indigenous isolate Pseudomonas aeruginosa J16. Process Biochem 43(7): 769-774.  [SCI]
(22)   Chien, C-C.* (2008) Taurine serves as sole source of nitrogen for aerobic and anaerobic growth by Klebsiella sp. World J Microbiol Biotechnol 24(6): 895-898. [SCI]
(23)   Chien, C-C.*, Kuo, Y-M., Chen, C-C., Hung, C-W., Yeh, C-W., Yeh, W-J. (2008) Microbial diversity of soil bacteria in agricultural field contaminated with heavy metals. J Environ Sci 20(3): 359-363. [SCI]
(24)   Su, F-H., Cheng, S-H., Li, C-Y., Chen, J-D., Hsiao, C-Y., Chien, C-C., Yang, Y- C., Hung, H-H., Chu, F-Y. * (2007) Hepatitis B seroprevalence and anamnestic response amongst Taiwanese young adults with full vaccination in infancy, twenty years subsequent to national hepatitis B vaccination. Vaccine 25(47): 8085-8090. [SCI]
(25)   Chien, C-C.*, Chen C-C, Choi, M-H., Kung, S-S., Wei, Y-H. (2007) Production of poly-ß-hydroxybutyrate (PHB) by Vibrio spp. isolated from marine environment. J Biotechnol 132(3):259-263. [SCI]
(26)   Kung, S-S., Chuang, Y-C., Chen, C-H., Chien, C-C*. (2007) Isolation of polyhydroxyalkanoates (PHAs) producing bacteria using a combination of phenotypic and genotypic approach. Lett Appl Microbiol 44:364-371. [SCI]
(27)   Chien, C-C.*, Hung, C-W., Han, C-T. (2007) Removal of cadmium ions during stationary growth phase by an extremely cadmium-resistant strain of Stenotrophomonas sp. Environ Toxicol Chem 26(4):664-668. [SCI]
(28)   Chien, C-C.* (2005) Arylsulfonates as sole source of sulfur for Clostridium pasteurianum DSM 12136. J Basic Microbiol 45(4): 274-278. [SCI]
 
B. 專書論著
 
(1)       Chien, C-C. (2008) Polyhydroxyalkanoates: In nature, in the laboratory and in industry. In: "Biotechnology: Research, Technology and Applications."  (Editor: Felix W. Richter) Nova Science Publishers, Inc. Hauppauge, NY, . pp. 47-70.
(2)       Chien, C-C.(2013) Heavy Metal Niches: Microbes and Their Metabolic Potentials. In: “Applications of Microbial Engineering.” (Editors: Vijai Kumar Gupta, Monika Schmoll, Marcio Antonio Mazutti, Minna Maki, Maria G. Tuohy) CRC Press, Taylor & Francis Group, Boca Raton, FL, USA. (ISBN 978-1-4665-8577-5) pp. 342-366.
 
C. 專利
 
(1)       簡志青,蘇伯琦,洪育芝,陳姍玗。「一種使大腸桿菌大量表現丙酸代謝相關基因與合成聚羥基丁酯-羥基戊酯之方法」。中華民國專利申請號:100135702
(2)       簡志青,蘇伯琦,洪育芝,陳姍玗。「藉由重組大腸桿菌以生產聚羥基丁酸酯(PHB)的方法」。中華民國專利申請號:100103238
(3)       簡志青,孫一明,康世旭,陳昌傑,何玲儀。「可使微生物利用不同碳源以合成PHA之方法」。中華民國專利I374190公告日:  1011011日。 
(4)       康世旭 (Kang, S-H.),孫一明 (Sun, Y-M.),簡志青 (Chien, C-C.),唐世珍 (Tang, S-C.),陳昌傑 (Chen, C-C.)Method for production of high purity polyhydroxyalkanoates (PHAs)US Patent 8053219 B2 (Nov 8, 2011)


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