學系成員

1. Hsiu-Jung Liao, Chih-Hung Chang, Yi-Shan Shen, Chi-Ying Huang. (2025 Mar) Cxcl14-based compositions and method for enhancing cartilage regeneration. US Patent App. 18/827,250
   
   
2. Jing-Gu Jiang, Yu-Chun Chen, Ni-En Jiang, Chun-Hsing Liao, Chih-Hung Chang. (2025 Feb) Unanticipated cytotoxicity of fusidic acid in antibiotic-loaded hydrogel. Journal of Microbiology, Immunology and Infection
   
   
3. Hsiu-Jung Liao, Chih-Hung Chang, Chi-Ying Huang, Ly James Lee, Tai-Shan Cheng, Sin-yu Chen. (2024 Dec) Method and pharmaceutical composition for treating a cartilage damage using sox9 gene. US Patent App. 18/737,607
   
   
4. Kai-Xuan Lim, Yun-Jer Shieh, Hsiu-Jung Liao, Tzu-Hung Hsiao, Chi-Ying F. Huang, Yi-Ling Hsieh, Chih-Hung Chang, Cheng-Hung Lee. (2024 Dec) Integrating polygenic risk scores and constructing a predictive model to assess the risk of knee osteoarthritis in Taiwanese population. Research Square.
5. Hsiu-Jung Liao, Hui-Ting Chen, Chih-Hung Chang. (2024 Sep) Peptides for Targeting Chondrogenic Induction and Cartilage Regeneration in Osteoarthritis. Cartiage 1-14.
   
   
6. Hsiu-Jung Liao, Yi-Ping Yang, Yu-Hao Liu, Huan-Chin Tseng, Teh-Ia Huo, Shih-Hwa Chiou, Chih-Hung Chang. (2024 Aug ) Harnessing the potential of mesenchymal stem cells-derived exosomes in degenerative diseases. Regenerative Therapy 26 (2024) 599-610
   
   
7. Ya-Lang Huang, Hsiu-Jung Liao, Chih-Hung Chang, Erin Chang, Frank Lee. (2024 Apr) Combined brm521 and human mesenchymal stem cell treatment improves articular cartilage pathology change in the anterior cruciate ligament transection induced mouse osteoarthritis model. Osteoarthritis and Cartilage. 32(S375-S376)
   
   
8. Hsiu-Jung Liao, Chih-Hung Chang. (2024 Apr) Use of joint-resident mesenchymal stromal cells for articular cartilage repair in degenerative knee osteoarthritis. Formosan Journal of Musculoskeletal Disorders. 15(2):p 43-48. 
   
   
   
9. Sin-Yu Chen, Yi-Ling Chen, Po-Chen Li, Tai-Shan Cheng, Yeh-Shiu Chu, Yi-Shan Shen, Hsin-Tung Chen, Wei-Ni Tsai, Chien-Ling Huang, Martin Sieber, Yuan-Chieh Yeh, Hsiao-Sheng Liu, Chi-Ling Chiang, Chih-Hung Chang, Andrew S Lee, Yen-Han Tseng, Ly James Lee, Hsiu-Jung Liao, Hon-Kan Yip, Chi-Ying F Huang. (2024 Mar) Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury. Journal of biomedical science. Volume 31 (30)
   
   
10. Thi Mai Nguyen, Pei‑Yi Wu, Chih‑Hung Chang, Li‑Fen Huang. (2024 Feb) High‑yield BMP2 expression in rice cells via CRISPR and endogenous αAmy3 promoter. Microbiology and Biotechnology. (2024) 108:206
    
    
11. Tsung-Yu Lan, Chin-Wen Chen, Yu-Hao Huang, Shang-Ming Lin, Ching-Ting Liang, Chih-Hung Chang & Syang-Peng Rwei. (2024 Jan) Biobased polyester versus synthetic fiberglass casts for treating stable upper limb fractures in children: a randomized controlled trial. BMC Musculoskeletal Disorders. (2024) 25:23
    
    
12. H.-W. Chen, C.-H. Huang, C.-Y. Huang, C.-H. Chang, H.-J. Liao. (2023 June) Distinct subsets of synovial fibroblasts control cartilage destruction in joint diseases. Clinical and Experimental Rheumatology. 
    
    
13. Hsiu-Jung Liao, Yi-Shan Shen, Ssu-Jung Lu, Ni-En Jiang, Chia-Ning Shen, Chih-Hung Chang. (2023 May) ADSC-derived exosomes inhibit cbl-cathepsin K-dependent osteoclast activation in inflammatory arthritis. The Journal of Immunology. Volume 210 (1) 
    
    
14. Chien-Cheng Lai, Hsu-Wei Fang , Chih-Hung Chang, Jwo-Luen Pao, Chun-Chien Chang, Yeong-Jang Chen. (2023 Mar) Unusual capitate fracture with dorsal shearing pattern and concomitant carpometacarpal dislocation with a 6-year follow-up: A case report. World J Clin Cases. 2023 Mar 26; 11(9): 2060-2066. 
    
    
15. Chia-Yin Lee, Anh Thuc Nguyen, Ly Hien Doan, Li-Wei Chu , Chih-Hung Chang, Hui-Kang Liu, I-Lin Lee, Teng-Hsu Wang, Jin-Mei Lai, Shih-Ming Tsao, Hsiu-Jung Liao  Yueh-Hsin Ping, Chi-Ying F Huang. (2023 Feb) Repurposing Astragalus Polysaccharide PG2 for Inhibiting ACE2 and SARS-CoV-2 Spike Syncytial Formation and Anti-Inflammatory Effects. Viruses. 2023 Feb27; 15(3): 641.
    
    
16. Cheng-Tzu Wang, Brady Huang, Nagaraju Thogiti, Wan-Xuan Zhu, Chih-Hung Chang, Jwo-Luen Pao, Feipei Lai.(2022 July) Successful real-world application of an osteoarthritis classification deep-learning model using 9210 knees—An orthopedic surgeon's view. Joural of Orthopaedic Research. 
    
    
17. Ting-Hui Chang, Chien-Sheng Wu, Shih-Hwa Chiou, Chih-Hung Chang and Hsiu-Jung Liao. (2022 Jul) Adipose-Derived Stem Cell Exosomes as a Novel Anti-Inflammatory Agent and the Current Therapeutic Targets for Rheumatoid Arthritis. Biomedicines. 10(7), 1725. 
    
    
18. Yu‐Chun Chen, Hsiu‐Jung Liao, Yuan‐Ming Hsu, Yi‐Shan Shen , and Chih‐Hung Chang. Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose‐Succinyl‐Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model. Polymers (2022),14,1474. 
    
    
19. Hsiu-Jung Liao ,Chih-Hung Chang ,Chi-Ying F. Huang and Hui-Ting Chen. Potential of Using Infrapatellar–Fat–Pad–Derived Mesenchymal tem Cells for herapy in Degenerative Arthritis: hondrogenesis, Exosomes, and Transcription Regulation. Biomolecules 2022, 12, 386.
    
    
20. Karl Wu , Yu-Chun Chen, Shang M Lin and Chih-Hung Chang. In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ ceramic bone substitute. (2021) Journal biomaterials applications.0(0):1-11 Hard Tissues and Materials.
21.  Hung-Hsuan Chen, Yu-Chun Chen, San-Ni Yu, Wan-Ling Lai, Pei-Chun Shen, Siao-Han Lin, ChihHung Chang*, Shing-Mou Lee*. Infrapatellar fat pad–derived mesenchymal stromal cell product for treatment of knee osteoarthritis: a first-in-human study with evaluation of the potency marker. 2021, Cytotherapy. (SCI) (Accepted)
22. Yen-Liang Liu, Chun-Che Yen, Tzu-Shang Thomas Liu, Chih-Hung Chang, Tiffany Ting-Fang Shih, Jyh-Horng Wang, Ming-Chia Yang, Feng-Huei Lin and Hwa-Chang Liu. (2021 Sep) Safety and Efficacy of Kartigen® in Treating Cartilage Defects: A Randomized, Controlled, Phase I Trial. Polymers. 13(3029). (SCI)
23. Hwa-Chang Liu, Tzu-Shang Thomas Liu, Yen-Liang Liu, Jyh-Horng Wang, Chih-Hung Chang, Tiffany Ting-Fang Shih, Feng-Huei Lin. (2021 May) Atelocollagen-embedded chondrocyte precursors as a treatment for Grade-4 cartilage defects of the femoral condyle: a case series with up to 9-year follow-up. Biomolecules. 11(7), 942. (SCI)
24. Karl Wu, Yu-Chun Chen, Shang M Lin, Chih-Hung Chang. (2021 May) In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ceramic bone substitute. Journal of Biomaterials Applications.;35(10);1355-1365. (SCI)
25. Chun-Hsing Liao, Chiang Sang Chen, Yu-Chun Chen, Ni-En Jiang, Chui Jia Farn, Yi-Shan Shen, MingLun Hsu, Chih-Hung Chang. (2020 Aug) Vancomycin-loaded oxidized hyaluronic acid and adipic acid dihydrazide hydrogel: Bio-compatibility, drug release, antimicrobial activity, and biofilm model. Journal of Microbiology, Immunology and Infection. 53:525-531. (SCI)
26. Jwo-Luen Pao, Shang-Ming Lin, Wen-Chi Chen, Chih-Hung Chang. (2020 Jun) Unilateral biportal endoscopic decompression for degenerative lumbar canal stenosis, Journal of Spine Surgery. 6(2):438- 446. (SCI)
27. Zhen Chang Liang, Mark Seng Ye Chong, Gabriel Ka Po Liu, Alejandro Gonzalez Della Valle, Dahui Wang, Xuemin Lyu, Chih-Hung Chang, Tae-Joon Cho, Steven B. Haas, Dale Fisher, Diarmuid Murphy, James Hoi Po Hui. (2020 May) COVID-19 and Elective Surgery: 7 Practical Tips for a Safe, Successful and Sustainable Reboot. Annals of Surgery: May 20, 2020 - Volume Publish Ahead of Print - Issue – (doi: 10.1097/SLA.0000000000004091) (SCI)
28. Ta-Li Hsu, Shang-Ming Lin, Chih-Hung Chang, Tsung-Yu Lan. (2019 Oct) Neglected Pediatric Osteochondral Fracture Dislocation of the Patella. Case Reports in Orthopedics. 2019:2904782. (SCI)
29. Yu-Chun Chen, Yu-Wei Chang, Kinn Poay Tan, Yi-Shan Shen, Yao- Horng Wang, Chih-Hung Chang*. (2018, Nov) Can mesenchymal stem cells and their conditioned medium assist inflammatory chondrocytes recovery? PLoS ONE.13(11): 0205563. (SCIE)
30. Yu-Chun Chen, Yuan-Ming Hsu, Kinn Poay Tan, Hsu-Wei Fang, Chih-Hung Chang*. (2018, Oct) Intraarticular injection for rabbit knee osteoarthritis: effectiveness among hyaluronic acid, platelet-rich plasma, and mesenchymal stem cells. Journal of the Taiwan Institute of Chemical Engineers. 91, 138- 145. (SCI)
31. Cheng-Tzu Wang, Jia-Wan Chen, Karl Wu, Chiang-Sang Chen, Wen-Chih Chen, Jwo-Luen Pao, Chih-Hung Chang and Tsung-Yu Lan. (2018 Jun) Suboptimal outcomes after closed reduction and internal fixation of displaced femoral neck fractures in middle-aged patients Is internal fixation adequate in this age group. BMC Musculoskeletal Disorders, 9;19(1):190. (SCIE)
32. Chih‑Kai Hong, Ming‑Long Yeh, I‑Ming Jou, Cheng‑Li Lin, Chih‑Hsun Chang, Chih‑Hung Chang, Wei‑Ren Su (2018 May). The effect of humeral-fenestration diameter in Outerbridge–Kashiwagi arthroplasty on failure load of the distal humerus: a cadaveric biomechanical study. Archives of Orthopaedic and Trauma Surgery, 138(5):623-628. (SCIE)
33. Chia Chun Chen, Chu Yun Hsiao, Yao Horng Wang, Yu Chun Chen, Chih Hung Chang, Hsu Wei Fang. (2017 Sep) A comparison of distinct bone marrow-derived cells on cartilage tissue engineering. Journal of the Taiwan Institute of Chemical Engineers; 78:32-38. (SCI)
34. Yeong-Jang Chen, Jwo-luen Pao, Chiang Sang Chen, Yu-Chun Chen, Chun-Chien Chang, Fang-Ming Hung, and Chih-Hung Chang. (2017 Jan). Evaluation of New Biphasic Calcium Phosphate Bone Substitute: Rabbit Femur Defect Model and Preliminary Clinical Results. J Med Biol Eng. 2017; 37(1): 85–93. (SCI)
35. Karl Wu, Yu-Chun Chen, Yuan-Ming Hsu, Chih-Hung Chang*. (2016 March) Enhancing Drug Release from Antibiotic-loaded Bone Cement Using Porogens. Journal of the American Academy of Orthopaedic Surgeons, 24(3): 188–195. (SCI)
36. Yuan-Ming Hsu, Chun-Hsing Liao, Yu-Hong Wei, Hsu-Wei Fang, Hsiang-Huan Hou, Chia-Chun Chen and Chih-Hung Chang*. (2014 Jun). Daptomycin-loaded polymethylmethacrylate bone cement for joint arthroplasty surgery. Artificial Organs, 38(6):484-92 (SCI)
37. Chih-Hung Chang*, Yuan-Ming Hsu, Yu-Chun Chen, Feng-Huei Lin, Subramaniam Sadhasivam, SiowTung Loo, Sivasubramanian Savitha. (2014 Apr). Anti-Inflammatory effects of hydrophilic and lipophilic statins with hyaluronic acid against LPS-induced inflammation in porcine articular chondrocytes. Journal of Orthopaedic Research, 32(4): 557-65. (SCI)
38. Chih-Hung Chang*, Chia-Chun Chen, Cheng-Hao Liao, Feng-Huei Lin, Yuan-Ming Hsu and Hsu-Wei Fang (2014, Jul). Human acellular cartilage matrix powders as a biological scaffold for cartilage tissue engineering with synovium-derived mesenchymal stem cells. Journal of Biomedical Materials Research: Part A, 102A: 2248-2257. (SCI)
39. Jwo-Luen Pao; Wen-Chih Chen; Chih-Hung Chang; Chiang-Sang Chen; Jaw-Lin Wang. 2014, Dec. Clinical Significance of Post-decompression Facet Joint Effusion After Minimally Invasive Decompression for Degenerative Lumbar Spinal Stenosis. Journal of Spinal Disorders and Techniques. 27(8): E318–E323 (SCI)
40. Wei-Chuan Chen, Wan-Ju Yu, Chia-Che Chang, Jo-Shu Chang, Shih-Horng Huang, Chih-Hung Chang, Shan-Yu Chen*, Chih-Ching Chien, Chao-Ling Yao, Wen-Ming Chen, and Yu-Hong Wei*. 2013, Sep. Enhancing production of prodigiosin from Serratia marcescens C3 by statistical experimental design and porous carrier addition strategy. Biochemical Engineering Journal, 78(15): 93-100. (SCI)
41. Tsung-Ching Lin, Hsing-Kuo Wang, Jia-Wine Chen, Cheng-Ming Chiu, Hsiu-Ling Chou, Chih-Hung Chang*. 2013. May. Minimally invasive knee arthroplasty with the subvastus approach allows rapid rehabilitation: a prospective, biomechanical, and observational study. Journal of Physical Therapy Science, 25(5): 55-5627. (SCI)
42. Chia-Chun Chen, Cheng-Hao Liao, Yao-Horng Wang, Yuan-Ming Hsu, Shih-Horng Huang, Chih-Hung Chang*, Hsu-Wei Fang*. 2012, Mar. Cartilage fragments from osteoarthritic knee promote chondrogenesis of mesenchymal stem cells without exogenous growth factor induction. Journal of Orthopaedic Research, 30(3): 393-400. (SCI)
43. Tsung-Yu Lan, Wei-Hsin Lin, Jih-Hsin Huang, Chih-Hung Chang, Rong-Sen Yang, Jui-Sheng Sun, Chih-Yu Chen*. 2012, Apr. Traumatic femoral vein rupture with compartment syndrome with concomitant closed femoral diaphyseal fracture: a case report. The Journal of Bone and Joint SurgeryAmerican Volume, 2(2): e18 1-4. (SCI)
44. Chih-Hung Chang, Hsin-Chun Lee, Chia-Chun Chen, Yi-Hau Wu, Yuan-Ming Hsu, Yin-Pen Chang, TaI Yang, Hsu-Wei Fang*. 2012, Jul. A novel rotating electrochemically anodizing process to fabricate titanium oxide surface nanostructures enhancing the bioactivity of osteoblastic cells. Journal of Biomedical Matrials Research PART A, 100(7): 1687-95. (SCI)
45. Wen-Chih Huang*, Chih-Hung Chang, Chien-Chen Tsai. 2012, Jan. Polyvinylpyrrolidone storage disease presenting as pathologic fracture and anemia: report of a case with imprint cytology. Diagnostic Cytopathology, 40(1): 69-72 (SCIE) 26. Karl Wu, Chih-Hung Chang*, Rong-Sen Yang. 2011, Nov. Comparing hook plates and Kirschner tension band wiring for unstable lateral clavicle fractures. Orthopedics, 34(11): e718-e723. (SCIE)
46. Hsin-Hua Liu, Karl Wu, Chih-Hung Chang*. 2011, May. Treatment of complex elbow injuries with a postoperative custom-made progressive stretching static elbow splint. Journal of Trauma-Injury Infection and Critical Care, 70(5): 1268-1272. (SCIE)
47. Chih-Hung Chang, Tzong-Fu Kuo, Feng-Huei Lin, Jyh-Horng Wang, Yuan-Ming Hsu, Huei-Ting Huang, Shiao-Tung Loo, Hsu-Wei Fang, Hwa-Chang Liu*, Wen-Chih Wang. 2011, Dec. Tissue engineeringbased cartilage repair with mesenchymal stem cells in a porcine model. Journal of Orthopaedic Research, 29(12): 1874-80. (SCI)
48. Shiu-Dong Chung, Chih-Hung Chang, Wu K, Chu SH. 2011, Jan. Post-acupuncture shoulder swelling. QJM –An international journal of medicine, 105(3): 281-282. (SCI)
49. Hsin-Hua Liu*, Chih-Hung Chang, Wei-Tso Chia, Chi-Hui Chen, Yi-Wen Tarng, Chi-Yin Wong. 2010, Dec. Comparison of plates versus intramedullary nails for fixation of displaced midshaft clavicular fractures. Journal of Trauma-Injury Infection and Critical Care, 69(6): e82-87. (SCIE)
50. Chih-Yu Chen, Chih-Hao Chang, Yung-Chang Lu, Chih-Hung Chang*, Chien-Chen Tsai, Chun-Hsiung Huang. 2010, Nov. Late foreign-body reaction after treatment of distal radial fractures with poly-L-lactic acid bioabsorbable implants: a report of three cases. The Journal of Bone and Joint Surgery-American Volume, 92(16): 2719-2724. (SCI)
51. Chih-Hung Chang*, Hsu-Wei Fang, Yi-Ching Ho, Chun-Yen Lin, Chun-Hsiung Huang, Charng-Bin Yang. 2010, Aug. Combined effects of polyethylene wear particle size and dosage on macrophage responses. Biomedical Engineering-Applications Basis Communications, 22 (4): 279-291. (SCIE)
52. Chih-Hung Chang, Rong-Sen Yang, Kuang-Ho Chen, Tang-Kue Liu, Wen-Chih Chen, Yi-Ching Ho, Sheng-Mou Hou*. 2010, Jul. Muscle torque in total knee arthroplasty: comparison of subvastus and midvastus approaches. Knee Surgery Sports traumatology Arthroscopy, 18(7): 934-938. (SCI)
53. Chih-Hung Chang, Tai-Chieh Liao, Yuan-Ming Hsu, Hsu-Wei Fang, Chia-Chun Chen, Feng-Huei Lin*. 2010, May. A poly (propylene fumarate)-calcium phosphate based angiogenic injectable bone cement for femoral head osteonecrosis. Biomaterials, 31(14): 4048-4055. (SCI)
54. Chih-Hung Chang, Siow-Tung Loo, Hsuan-Liang Liu, Hsu-Wei Fang, Hsin-Yi Lin*. 2010, Mar. Can low frequency electromagnetic field help cartilage tissue engineering? Journal of Biomedical Materials Research: Part A, 92(3): 843-851. (SCI)
55. Chih-Hung Chang, Hsin-Yi Lin, Hsu-Wei Fang, Siow-Tung Loo, Shih-Chieh Hung, Yi-Ching Ho, ChiaChun Chen, Feng-Huei Lin* and Hwa-Chang Liu* (2008, Jul). Chondrogenesis from immortalized human mesenchymal stem cells: comparison between collagen gel and pellet culture methods. Artificial Organs, 32(7): 561-566. (SCI)
56. Chih-Hung Chang, Hsu-Wei Fang*, Yi-Ching Ho, Huei-Ting Huang (2008, May). Chondrocyte acting as phagocyte to internalize polyethylene wear particles and leads to the elevations of osteoarthritis associated NO and PGE2. Biochemical and Biophysical Research Communications, 369(3): 884-888. (SCI)
57. Ming-Hsiao Hu, Wen-Chih Chen* and Chih-Hung Chang (2008, Jan). Idiopathic osteonecrosis of the third metacarpal head. Journal of the Formosan Medical Association, 107(1): 89-92. (SCI)
58. Chih-Hung Chang, Hsu-Wei Fang*, Huei-Ting Huang, Hsuan-Liang Liu, Wei-Ming Lee, Man-Ching Hsieh, Chiang-San Chen (2007, Jun). Tribological process induced conformational transformation of protein may change the friction of articular cartilage. Materials Letters, 61(16): 3381-3384. (SCI)
59. Hsu-Wei Fang*, Meng-Lin Shih, Jian-Hua Zhao, Huei-Ting Huan, Hsin-Yi Lin, Hsuan-Liang Liu, ChihHung Chang, Charng-Bin Yang, Hwa-Chang Liu (2007, Jun). Association of polyethylene friction and thermal unfolding of interfacial albumin molecules. Applied Surface Science, 253(16): 6896-6904. (SCI)
60. Charng-Bin Yang, Hsu-Wei Fang*, Hsuan-Liang Liu, Chih-Hung Chang, Man-Ching Hsieh, Wei-Ming Lee, Huei-Ting Huang (2006, Nov). Frictional characteristics of the tribological unfolding albumin for polyethylene and cartilage. Chemical Physicals Letters, 431(4-6): 380-384. (SCI)
61. Hsu-Wei Fang*, Charng-Bin Yang, Chih-Hung Chang, Chun-Hsiung Huang, Hsuan-Liang Liu, ShuBin Fang (2006, Nov). The Potential Role of Phagocytic Capacity in the Osteolytic Process Induced by Polyethylene Wear Particles. Journal of International Medical Research, 34(6): 655-664. (SCI)
62. Cheng-Hung Chou, Winston T. K. Cheng, Chien-Cheng Lin, Chih-Hung Chang, Chien-Chen Tsai and Feng-Huei Lin* (2006, May). TGF-beta1 immobilized tri-co-polymer for articular cartilage tissue engineering. Journal of Biomedical Materials Research: Part B, 77B (2): 338-348. (SCI)
63. Chih-Hung Chang, Tzong-Fu Kuo, Chien-Cheng Lin, Cheng-Hung Chou, Kuang-Ho Chen, Feng-Huei Lin* and Hwa-Chang Liua* (2006, May). Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin-chondroitin-hyaluronan tri-copolymer scaffold: A porcine model assessed at 18, 24, and 36 weeks. Biomaterials., 27(9): 1876-1888. (SCI)
64. Chih-Hung Chang, Feng-Huei Lin, Chien-Cheng Lin, Cheng-Hung Chou and Hwa-Chang Liu* (2004, Nov). Cartilage tissue engineering on the surface of a novel gelatin-calcium-phosphate biphasic scaffold in a double-chamber bioreactor. Journal of Biomedical Materials Research: Part B, 71(2):313-21. (SCI)
65. Chih-Hung Chang, Hwa-Chang Liu, Chien-Cheng Lin, Cheng-Hung Chou, Feng-Huei Lin* (2003, Nov). Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering. Biomaterials, 24(26): 4853-4858. (SCI)
66. Chih-Hung Chang, Kuang-Ho Chen, Rong-Sen Yang, Tang-Kue Liu (2002, May). Muscle Torques in Total Knee Arthroplasty with Subvastus and Parapatellar Approaches. Clinical orthopaedics and related research, 398: 189-195. (SCI)
67. J-S Sun, T T-F Shih, C-M Ko, Chih-Hung Chang, Y S Hang, S-M Hou. (2000) In Vivo Kinematic Study of Normal Wrist Motion: An Ultrafast Computed Tomographic Study. Clin Biomech 15:212-6. (SCI)
68. Chih-Hung Chang, Yi-Shiun Tsai, Jui-Sheng Sun, Sheng-Mou Hou (2000) Ipsilateral Distal Radius and Scaphoid Fractures. J Formos Med Assoc. 99: 733-7. (SCI)
69. Chih-Hung Chang and Shier-Chieg Huang: Clubfoot Deformity in Congenital Constriction Band Syndrome: Manifestations and Treatment (1998) J Formos Med Assoc 97:328-34. (SCI)
70. Chih-Hung Chang and Ching-Chuan Jiang (1997): Evaluation of Critical Postoperative Situations in Orthopedic Patients. J Formos Med Assoc 96: 990-5. (SCI)

Non-SCI Publications

1. 張至宏、廖秀蓉、雷涵婾、陳郁君。2021，Apr。 “退化性關節炎與軟骨缺損的再生醫學治療“ 高 雄醫師會誌，29(1), 72-81.
2. Karl Wu, Chih-Hung Chang, Rong-Sen Yang. 2012, May. Orthogeriatric care and treatment of fragility fractures in the elderly. Taiwan Geriatrics & Gerontology, 7(2): 91-104.
3. Cheng-Wei Wang, Yen-Yu Chen, Ka-Chon Wu, Chih-Hung Chang, Chiang-Sang Chen. 2011, Aug. Case Report-Digital gangrenes after distal radius fracture. Formosan Journal of Musculoskeletal Disorders, 2: 109-112.
4. 吳凱文、陳致宇、張至宏、楊榮森。2010，Feb。“雙磷酸鹽藥物於癌症骨轉移的治療應用”台灣老 年醫學暨老年學雜誌 Taiwan Geriatrics & Gerontology，5(1):1-12.
5. 張至宏、陳佳君、林峰輝、劉華昌、方旭偉。2009，Sep。“幹細胞於關節軟骨組織工程之新進展” 台灣醫學 Formosa Journal of Medicine，13:(5): 488-494.

International Conference

1. Chih-Hung Chang Clinical application of MSCs for cartilage defect and OA. 2024RCOST 
2. Chih-Hung Chang Development of engineered Exosome and novel peptide for OA treatment. 2024RCOST 
3. Chih-Hung Chang Advanced Engineered Mesenchymal Stem cellsderived Extracellular Vesicles Activates Chondrogenesis for Cartilage Regeneration in Osteoarthritis. 17th ICRS World Congress 
4. Hsiu-Jung Liao, Tai-Shan Cheng, Yi-Shan Shen, Sin Yu Chen, Kai-Xuan Lim, Ssu-Jung Lu, Ly James Lee*, Chi-Ying Huang*, Chih-Hung Chang* Advanced Engineered Mesenchymal Stem cells-derived Extracellular Vesicles Activates Chondrogenesis for Cartilage Regeneration in Osteoarthritis. International Congress of Korean Knee Society 2023 The 41st Annual Congress of Korean Knee Society 
5. Hsiu-Jung Liao, Yi-Shan Shen, Ssu-Jung Lu, Chia-Ning Shen, Chih-Hung Chang. DSC-derived exosomes inhibit cbl-cathepsin K-dependent osteoclast activation in inflammatory arthritis / IMMUNOLOGY2023 
6. Chih-Hung Chang. Treatment of Knee Osteoarthritis with Autologous Mesenchymal Stromal Cell Product. / 2020 European Orthopaedic Research Society, Izmir. 
7. Chih-Hung Chang. Clinical Trial of Cartilage Defect and OA Treatment Using BMMSC and IPFP MSC. Clinical Application of Cell Therapy in Regenerative Medicine / 2019 International Annual Meeting of FARM, Taipei, Taiwan. 
8. Chih-Hung Chang. Regenerative Researches for Cartilage Defect and Osteoarthritis in Taiwan. 2nd Annual Summer Meeting of Korean Society of Cartilage and Osteoarthritis, Seoul, Korea. 
9. *Chih-Hung Chang, Yu-Chun Chen, Yi-Shan Shen, Feng-Hui Lin. In Situ Forming Thermosensitive Hydrogel Combined with ACM for One-stage Cartilage Defect Treatment. 14th World Congress of the International Cartilage Repair Society (2018 ICRS), Macao, China.
10. *Chih-Hung Chang, Yu-Chun Chen, Ni-En Jiang, Chun-Hsing Liao, Ming-Lun Hsu, Chui-Jia Farn. Development of a Thermo-sensitive Antibacterial Hyaluronic Based Hydrogel for Orthopedic Implant Coating Use. Orthopaedic Research Society (ORS),2018, New Orleans, LA.
11. *Chih-Hung Chang, Jyh-Horng Wang, Feng-Huei Lin4 Tzu-Shang Thomas Liu, Hwa-Chang Liu. Tissue Engineered Cartilage Repair: Results of Clinical Trial in Taiwan. 2017 ISAKOS Congress, Shanghai, China. 2017 June.
12. *Chih-Hung Chang, Yu-Chun Chen, Yu-Wei Chang, Kinn Poay Tan, Yi-Shan Shen, Yao-Horng Wang. Using Mesenchymal Stem Cells to Treat Inflammatory Chondrocytes: Conditioned Medium Is Better than Co-culture System. 2016 International Cartilage Repair Society, Sorrento-Naples, Italy. 2016 Sep.
13. Chih-Hung Chang, Hwa-Chang Liu. Restoration of Articular Cartilage Defect with Kartigen® . 2016 Tissue Engineering and Regenerative Medicine International Society- Asia Pacific Meeting, New Taipei City, Taiwan. 2016 Sep.
14. Yu-Chun Chen, Ruo-Yu Chen, Yuan-Ming Hsu and Chih-Hung Chang. Acellular Cartilage Matrix Combined with Chitosan Cellulose Hydrogel for Cartilage Regeneration: Cellcompatibility and Gene Expression Analysis. 2016 Tissue Engineering and Regenerative Medicine International Society- Asia Pacific Meeting, New Taipei City, Taiwan. 2016 Sep.
15. Yu-Chun Chen, Yi-Shan Shen, Feng–Hui Lin, Chih-Hung Chang. Evaluation the Anti-inflammation and Anti-Apoptosis Abilities of Mesenchymal Stem Cell by Chondrocyte/ Wharton’s Jelly Mesenchymal Cells (WJMC) Co-culture System. 2016 Tissue Engineering and Regenerative Medicine International Society- Asia Pacific Meeting, New Taipei City, Taiwan. 2016 Sep.
16. *Chih-Hung Chang. Matrix Effect on Chondrogenesis: Implication on Cartilage Repair. 2015 International Society of Arthroscopy, Knee Surgery and Orhtopaedic Sports Medicine, Lyon, France. 2015 June. (invited speaker)
17. Yu-Chun Chen, Yuan-Ming Hsu, Kinn Poay Tan, *Chih-Hung Chang, Comparison of Platelet-rich Plasma or Hyaluronic Acid with/without Bone Marrow Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis in a Rabbit Model. Asia-Pacific Knee, Arthroscopy and Sports Medicine Society Summit, Taipei, Taiwan. 2015 May. (invited speaker)
18. *Chih-Hung Chang. Stem Cell and Cartilage Repair. 2015 Asian Cartilage Repair Society, Bangsar South, Kuala Lumpur. 2015 Oct. (invited speaker)
19. *Chih-Hung Chang. Extracellular Matrix Modulation on Cartilage Tissue Engineering: From Synthetic, Nature to Acellular. 2014 Global Conference on Biomedical Engineering, Tainan, Taiwan. 2014 Oct. (invited speaker)
20. Chih-Hung Chang, Yuan-Ming Hsu, Chun-Hsing Liao. Feasibility of Daptomycin-Loaded polymethylmethacrylate bone cement for Infection prophylaxis in joint arthroplasty surgery. 2013 ORS Annual Meeting, San Antonio, Texas. 2013 Jan.
21. Chih-Hung Chang, Jia-Si Hu, Chia-Chun Chen, Hsu-Wei Fang, Yuan-Ming Hsu. The effects of articular cartilage fragments and synovial membranes on chondrogenesis of bone marrow-derived mesenchymal stem cells. 2012 World Congress on Osteoarthritis. Barcelona, Spain, April 26-29.
22. Chih-Hung Chang, Po-Yang Chen, Hsiang-Huan Hou, Jo-Wei Huang, Ken-Yuan Chang, Yuan-Ming Hsu. Development of a hyaluronic acid incorporated hydroxyapatite/calcium sulfate bone cement for promoting bone reconstruction. SICOT 2011 XXV Triennial World Congress, Prague, Czech Republic.
23. Yuan-Ming Hsu, Hsiang-Huan Hou, Feng-Huei Lin, Chih-Hung Chang. In situ gelling cell-laden hydrogel as injectable cartilage tissue engineered implant. SICOT 2011 XXV Triennial World Congress, Prague, Czech Republic.
24. Chih-Hung Chang, Tai-Chieh Liao, Yuan-Ming Hsu, Feng-Huei Lin. Development of a novel angiogenic composite as injectable bone cement for osteonecrosis of femoral head. 2010, 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, USA.
25. Chih-Hung Chang. Proximal humeral fracture with posterior shoulder dislocation: an easily neglected injury. 2010, 3rd North Asian Trauma Summit, Seoull, Korea.
26. Hsu YM, Liao CH, Fang HW, Chang CH. Cartilage tissue engineering with acellular cartilage matrix and synovial stem cells. 2010, 9th World Congress of the International Cartilage Repair Society, Barcelona, Spain.
27. Chen CC, Chang CH, Fang HW, Liao CH. A strategy of using cartilage fragments for chondrogenesis of MSC. 2010, 9th World Congress of the International Cartilage Repair Society, Barcelona, Spain.
28. Chang CH. The effect of extracellular matrix on cartilage tissue engineering: from bio-mimetic scaffold to natural derived ECM. 2010, International Symposium of Materials on Regenerative Medicine, Zhunan, Taiwan.
29. Hsu YM, Hou HH, Lin FH, Fang HW, Chen CC, Chang CH. Characterization of a novel cellulose/chitosan based hydrogel for cartilage tissue engineering. 2010, International Symposium of Materials on Regenerative Medicine, Zhunan, Taiwan.
30. Hsu YM, Hou HH, Fang HW, Chen CC, Chang CH. Development of daptomycin premixed PMMA bone cement for infection prevention. 2010, International Symposium of Materials on Regenerative Medicine, Zhunan, Taiwan.
31. Hsu YM, Hou HH, Fang HW, Chen CC, Chang CH. In vivo assessment of a hydroxyapatite/calcium sulfate bone cement in a rabbit model. 2010, International Symposium of Materials on Regenerative Medicine, Zhunan, Taiwan.
32. Lee HC, Chen CC, Fang HW, Hsu YM, Chang CH, Osteointegration Enhanced Titanium Implants by Surface Modification with Anodic Oxidized Nanowires. 2010, International Symposium of Materials on Regenerative Medicine, Zhunan, Taiwan.
33. Chia-Chun Chen, Cheng-Hao Liao, Hsu-Wei Fang, Chih-Hung Chang. Chondrogenesis of mesenchymal stem cells by using osteoarthritic cartilage matrix fragments. 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) 2010.
34. Yuan-Ming Hsu, Hsiang-Huan Hou, Shih-Horng Huang, Chun-Hsing Liao, Hsu-Wei Fang, Chia-Chun Chen, Chih-Hung Chang. In vitro assessments of the daptomycin-loaded PMMA bone cement.16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) 2010.
35. Yuan-Ming Hsu, Hsiang-Huan Hou, Hsu-Wei Fang, Chia-Chun Chen, Feng-Huei Lin, Chih-Hung Chang. Development of a dialdehyde methyl cellulose/succinyl chitosan injectable hydrogel for cartilage repair. 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) 2010.
36. Cheng-Hao Liao, Chia-Chun Chen, Hsu-Wei Fang, Yuan-Ming Hsu, Chih-Hung Chang. Applying synovial mesenchymal stem cells and acellular cartilage matrix for cartilage tissue engineering. 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) 2010.
37. Yuan-Ming Hsu, Hsiang-Huan Hou, Hsu-Wei Fang, Chia-Chun Chen, Chih-Hung Chang. Evaluation of a hydroxyapatite/calcium sulfate biodegradable bone cement. 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) 2010.
38. Chang CH, Liao TC, Hsu YM, Lin FH. Development of A Novel Angiogenic Composite as injectable bone cement for osteonecrosis of femoral head. 2010, 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, USA.

研究計畫

科技部

亞東醫院院內計畫

亞東醫院與院外之合作計畫

技術報告, 專利及其他

1. 張至宏 林峰輝: 源源不絕的骨骼銀行, 談硬骨組織工程. 科學發展2002: 356 期 p 18-21. 行政院國家科學委員會
2. Chih-Hung Chang, Hwa-Chang Liu and Feng-Huei Lin: Fabrication of Double-Chamber Bioreactor for osteochondral tissue engineering. USA and Japan patent pending.
3. 陳佳萬, 鄭誠功, 侯勝茂, 黃佩珊, 張至宏: 復健手套, 握把, 及與該手套, 握把配合的手部復健裝置. 中華民國專利証書: 新型第M 二四八四三五號.
4. 侯勝茂, 張至宏, 陳佳萬, 周重維,:靜態可調整式支架. 中華民國專利証書: 新型第M258716 號.
5. 陳佳萬, 張至宏: 具有可調整功能之鞋墊結構. 中華民國專利証書: 新型第M262043號

2020 遠東精神獎 優等

2019 20th Anniversary International Meeting of Korean Tissue Engineering and Regenerative Medicine Society(2019 KTERMS) 受邀演講

2019 49th Malaysian Orthopaedic Association Annual Scientific Meeting / Annual General Meeting 2019 (MOA) 受邀演講

2019 Clinical Application of Cell Therapy in Regenerative Medicine / 2019 International Annual Meeting of FARM 受邀演講

2018 2nd Annual Summer Meeting of Korean Society of Cartilage and Osteoarthritis 受邀演講

2018 Annual Meeting of Taiwan Arthroscopy and Knee Society 受邀演講

2017 JMBE Annual Excellent Paper Award

2015 International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS 2015 Lyon, France) 受邀演講

2014 3rd New Taipei Medical Charity Award : Educational Research Award (新北市醫療公益獎教育研究獎)

2014 Asian Cartilage Repair Society (ACRS) 2nd Annual Congress 受邀演講

2014 第九屆亞太生物醫學工程會議(APCMBE 2014) 受邀演講

2014 1st Global Conference on Biomedical Engineering (GCBME) 受邀演講

2014 Asian Mayo Clinic Morrey Elbow Club Facaulty

2014 台灣骨科研究學會 SCI 論文獎第三名

2013 2013 年台北國際發明暨技術交易展：鉑金獎

2011 第八屆 國家新創獎

2010 第八屆 有庠科技獎：傑出教授獎

2010 亞東紀念醫院 第八屆 年度卓越研究論文獎：銅牌獎

2008 第五屆 國家新創獎

2008、2009、2010

2011、2012、2016 國際外科醫學會優秀論文獎

2006、2008、2014 中華骨科醫學會優秀論文獎

2003 第三屆 APOA 亞太骨科協會：優秀壁報論文獎

2002 生物醫學工程科技研討會：博士班壁報論文競賽特優獎第一名